%PDF-1.4
%
1 0 obj
<<
/Type /Catalog
/Version /1.6
/Pages 2 0 R
/PageLabels 3 0 R
/Metadata 4 0 R
/AcroForm 5 0 R
/Outlines 6 0 R
>>
endobj
7 0 obj
<<
/CreationDate (D:20190411083246+05'30')
/Subject (Journal of Extracellular Vesicles, 2019. doi:10.1080/20013078.2019.1599680)
/Author (Luyen Tien Vu)
/Creator (Arbortext Advanced Print Publisher 11.0.3433/W Unicode)
/Keywords (Extracellular vesicles; microRNAs; cancer-associated fibroblasts; breast cancer)
/Producer (Acrobat Distiller 8.1.0 \(Windows\))
/ModDate (D:20190411083317+05'30')
/Title (Tumor-secreted extracellular vesicles promote the activation of cancer-associated fibroblasts via th)
>>
endobj
2 0 obj
<<
/Type /Pages
/Kids [8 0 R 9 0 R 10 0 R 11 0 R 12 0 R 13 0 R 14 0 R 15 0 R 16 0 R 17 0 R
18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R
28 0 R 29 0 R 30 0 R 31 0 R 32 0 R]
/Count 25
>>
endobj
3 0 obj
<<
/Nums [0 33 0 R]
>>
endobj
4 0 obj
<<
/Length 5270
/Subtype /XML
/Type /Metadata
>>
stream
application/pdf
10.1080/20013078.2019.1599680
en
Tumor-secreted extracellular vesicles promote the activation of cancer-associated fibroblasts via the transfer of microRNA-125b
Luyen Tien Vu
Boya Peng
Daniel Xin Zhang
Victor Ma
Camille A. Mathey-Andrews
Chun Kuen Lam
Theodoros Kiomourtzis
Jingmin Jin
Larry McReynolds
Linfeng Huang
Andrew Grimson
William C. Cho
Judy Lieberman
Minh Tn Le
Taylor & Francis
Journal of Extracellular Vesicles, 2019. doi:10.1080/20013078.2019.1599680
Extracellular vesicles
microRNAs
cancer-associated fibroblasts
breast cancer
Journal
Journal of Extracellular Vesicles
© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of The International Society for Extracellular Vesicles.
2001-3078
8
1
10.1080/20013078.2019.1599680
https://doi.org/10.1080/20013078.2019.1599680
VoR
2019-04-11T08:32:46+05:30
Arbortext Advanced Print Publisher 11.0.3433/W Unicode
2019-04-11T08:33:17+05:30
2019-04-11T08:33:17+05:30
Extracellular vesicles; microRNAs; cancer-associated fibroblasts; breast cancer
Acrobat Distiller 8.1.0 (Windows)
uuid:818cf7dc-92f4-4a69-95fa-184c94983c36
uuid:2239f020-0e87-4aeb-a57b-ba61c0266eee
10.1080/20013078.2019.1599680
2019-04-14
True
www.tandfonline.com
10.1080/20013078.2019.1599680
2019-04-14
True
www.tandfonline.com
endstream
endobj
5 0 obj
<<
/Fields []
/DA (/Helv 0 Tf 0 g )
/DR 34 0 R
/SigFlags 2
>>
endobj
6 0 obj
<<
/First 35 0 R
/Count 10
/Last 36 0 R
/Type /Outlines
>>
endobj
8 0 obj
<<
/Resources 37 0 R
/Type /Page
/MediaBox [0.0 0.0 634.32 833.04]
/CropBox [0.0 0.0 634.32 833.04]
/BleedBox [0 0 634.32 833.04]
/TrimBox [0 0 634.32 833.04]
/Parent 2 0 R
/Annots [38 0 R 39 0 R 40 0 R 41 0 R 42 0 R 43 0 R 44 0 R 45 0 R 46 0 R 47 0 R
48 0 R 49 0 R 50 0 R 51 0 R]
/Contents 52 0 R
/Rotate 0
>>
endobj
9 0 obj
<<
/CropBox [0.0 0.0 609.449 793.701]
/Annots [53 0 R 54 0 R 55 0 R 56 0 R 57 0 R 58 0 R 59 0 R 60 0 R 61 0 R 62 0 R
63 0 R 64 0 R 65 0 R 66 0 R 67 0 R 68 0 R 69 0 R 70 0 R 71 0 R 72 0 R
73 0 R 74 0 R 75 0 R 76 0 R 77 0 R 78 0 R 79 0 R 80 0 R 81 0 R 82 0 R
83 0 R 84 0 R 85 0 R 86 0 R 87 0 R 88 0 R 89 0 R 90 0 R 91 0 R]
/Parent 2 0 R
/Contents [92 0 R 93 0 R 94 0 R 95 0 R 96 0 R 97 0 R 98 0 R 99 0 R]
/Rotate 0
/MediaBox [0.0 0.0 609.449 793.701]
/Resources 100 0 R
/Type /Page
>>
endobj
10 0 obj
<<
/CropBox [0.0 0.0 609.449 793.701]
/Annots [101 0 R 102 0 R 103 0 R 104 0 R 105 0 R 106 0 R 107 0 R 108 0 R 109 0 R 110 0 R
111 0 R 112 0 R 113 0 R 114 0 R 115 0 R 116 0 R 117 0 R 118 0 R]
/Parent 2 0 R
/Contents 119 0 R
/Rotate 0
/MediaBox [0.0 0.0 609.449 793.701]
/Resources 120 0 R
/Type /Page
>>
endobj
11 0 obj
<<
/CropBox [0.0 0.0 609.449 793.701]
/Annots [121 0 R]
/Parent 2 0 R
/Contents 122 0 R
/Rotate 0
/MediaBox [0.0 0.0 609.449 793.701]
/Resources 123 0 R
/Type /Page
>>
endobj
12 0 obj
<<
/CropBox [0.0 0.0 609.449 793.701]
/Annots [124 0 R]
/Parent 2 0 R
/Contents 125 0 R
/Rotate 0
/MediaBox [0.0 0.0 609.449 793.701]
/Resources 126 0 R
/Type /Page
>>
endobj
13 0 obj
<<
/CropBox [0.0 0.0 609.449 793.701]
/Annots [127 0 R 128 0 R 129 0 R 130 0 R 131 0 R 132 0 R 133 0 R 134 0 R 135 0 R 136 0 R
137 0 R 138 0 R 139 0 R 140 0 R 141 0 R 142 0 R 143 0 R 144 0 R 145 0 R 146 0 R
147 0 R 148 0 R 149 0 R 150 0 R 151 0 R 152 0 R]
/Parent 2 0 R
/Contents 153 0 R
/Rotate 0
/MediaBox [0.0 0.0 609.449 793.701]
/Resources 154 0 R
/Type /Page
>>
endobj
14 0 obj
<<
/CropBox [0.0 0.0 609.449 793.701]
/Annots [155 0 R 156 0 R 157 0 R 158 0 R 159 0 R 160 0 R 161 0 R]
/Parent 2 0 R
/Contents 162 0 R
/Rotate 0
/MediaBox [0.0 0.0 609.449 793.701]
/Resources 163 0 R
/Type /Page
>>
endobj
15 0 obj
<<
/CropBox [0.0 0.0 609.449 793.701]
/Annots [164 0 R 165 0 R 166 0 R]
/Parent 2 0 R
/Contents 167 0 R
/Rotate 0
/MediaBox [0.0 0.0 609.449 793.701]
/Resources 168 0 R
/Type /Page
>>
endobj
16 0 obj
<<
/CropBox [0.0 0.0 609.449 793.701]
/Annots [169 0 R]
/Parent 2 0 R
/Contents 170 0 R
/Rotate 0
/MediaBox [0.0 0.0 609.449 793.701]
/Resources 171 0 R
/Type /Page
>>
endobj
17 0 obj
<<
/CropBox [0.0 0.0 609.449 793.701]
/Annots [172 0 R 173 0 R 174 0 R 175 0 R 176 0 R 177 0 R 178 0 R 179 0 R 180 0 R 181 0 R
182 0 R 183 0 R 184 0 R 185 0 R 186 0 R 187 0 R 188 0 R 189 0 R 190 0 R 191 0 R
192 0 R 193 0 R]
/Parent 2 0 R
/Contents 194 0 R
/Rotate 0
/MediaBox [0.0 0.0 609.449 793.701]
/Resources 195 0 R
/Type /Page
>>
endobj
18 0 obj
<<
/CropBox [0.0 0.0 609.449 793.701]
/Parent 2 0 R
/Contents 196 0 R
/Rotate 0
/MediaBox [0.0 0.0 609.449 793.701]
/Resources 197 0 R
/Type /Page
>>
endobj
19 0 obj
<<
/CropBox [0.0 0.0 609.449 793.701]
/Annots [198 0 R 199 0 R]
/Parent 2 0 R
/Contents 200 0 R
/Rotate 0
/MediaBox [0.0 0.0 609.449 793.701]
/Resources 201 0 R
/Type /Page
>>
endobj
20 0 obj
<<
/CropBox [0.0 0.0 609.449 793.701]
/Annots [202 0 R 203 0 R 204 0 R 205 0 R 206 0 R 207 0 R 208 0 R 209 0 R 210 0 R 211 0 R
212 0 R 213 0 R 214 0 R 215 0 R 216 0 R 217 0 R 218 0 R 219 0 R 220 0 R 221 0 R
222 0 R 223 0 R 224 0 R 225 0 R 226 0 R 227 0 R 228 0 R 229 0 R 230 0 R 231 0 R]
/Parent 2 0 R
/Contents 232 0 R
/Rotate 0
/MediaBox [0.0 0.0 609.449 793.701]
/Resources 233 0 R
/Type /Page
>>
endobj
21 0 obj
<<
/CropBox [0.0 0.0 609.449 793.701]
/Parent 2 0 R
/Contents 234 0 R
/Rotate 0
/MediaBox [0.0 0.0 609.449 793.701]
/Resources 235 0 R
/Type /Page
>>
endobj
22 0 obj
<<
/CropBox [0.0 0.0 609.449 793.701]
/Annots [236 0 R 237 0 R]
/Parent 2 0 R
/Contents 238 0 R
/Rotate 0
/MediaBox [0.0 0.0 609.449 793.701]
/Resources 239 0 R
/Type /Page
>>
endobj
23 0 obj
<<
/CropBox [0.0 0.0 609.449 793.701]
/Parent 2 0 R
/Contents 240 0 R
/Rotate 0
/MediaBox [0.0 0.0 609.449 793.701]
/Resources 241 0 R
/Type /Page
>>
endobj
24 0 obj
<<
/CropBox [0.0 0.0 609.449 793.701]
/Annots [242 0 R 243 0 R 244 0 R 245 0 R 246 0 R 247 0 R 248 0 R 249 0 R 250 0 R 251 0 R
252 0 R 253 0 R 254 0 R 255 0 R 256 0 R 257 0 R 258 0 R 259 0 R 260 0 R 261 0 R
262 0 R 263 0 R 264 0 R 265 0 R 266 0 R 267 0 R 268 0 R 269 0 R 270 0 R 271 0 R
272 0 R 273 0 R]
/Parent 2 0 R
/Contents 274 0 R
/Rotate 0
/MediaBox [0.0 0.0 609.449 793.701]
/Resources 275 0 R
/Type /Page
>>
endobj
25 0 obj
<<
/CropBox [0.0 0.0 609.449 793.701]
/Annots [276 0 R 277 0 R 278 0 R 279 0 R 280 0 R 281 0 R 282 0 R 283 0 R]
/Parent 2 0 R
/Contents 284 0 R
/Rotate 0
/MediaBox [0.0 0.0 609.449 793.701]
/Resources 285 0 R
/Type /Page
>>
endobj
26 0 obj
<<
/CropBox [0.0 0.0 609.449 793.701]
/Annots [286 0 R 287 0 R 288 0 R 289 0 R 290 0 R 291 0 R]
/Parent 2 0 R
/Contents 292 0 R
/Rotate 0
/MediaBox [0.0 0.0 609.449 793.701]
/Resources 293 0 R
/Type /Page
>>
endobj
27 0 obj
<<
/CropBox [0.0 0.0 609.449 793.701]
/Parent 2 0 R
/Contents 294 0 R
/Rotate 0
/MediaBox [0.0 0.0 609.449 793.701]
/Resources 295 0 R
/Type /Page
>>
endobj
28 0 obj
<<
/CropBox [0.0 0.0 609.449 793.701]
/Annots [296 0 R]
/Parent 2 0 R
/Contents 297 0 R
/Rotate 0
/MediaBox [0.0 0.0 609.449 793.701]
/Resources 298 0 R
/Type /Page
>>
endobj
29 0 obj
<<
/CropBox [0.0 0.0 609.449 793.701]
/Annots [299 0 R]
/Parent 2 0 R
/Contents 300 0 R
/Rotate 0
/MediaBox [0.0 0.0 609.449 793.701]
/Resources 301 0 R
/Type /Page
>>
endobj
30 0 obj
<<
/CropBox [0.0 0.0 609.449 793.701]
/Parent 2 0 R
/Contents 302 0 R
/Rotate 0
/MediaBox [0.0 0.0 609.449 793.701]
/Resources 303 0 R
/Type /Page
>>
endobj
31 0 obj
<<
/CropBox [0.0 0.0 609.449 793.701]
/Annots [304 0 R 305 0 R 306 0 R 307 0 R 308 0 R 309 0 R 310 0 R 311 0 R 312 0 R 313 0 R
314 0 R 315 0 R 316 0 R 317 0 R 318 0 R 319 0 R 320 0 R 321 0 R 322 0 R 323 0 R]
/Parent 2 0 R
/Contents 324 0 R
/Rotate 0
/MediaBox [0.0 0.0 609.449 793.701]
/Resources 325 0 R
/Type /Page
>>
endobj
32 0 obj
<<
/CropBox [0.0 0.0 609.449 793.701]
/Annots [326 0 R 327 0 R 328 0 R 329 0 R 330 0 R 331 0 R 332 0 R 333 0 R 334 0 R 335 0 R
336 0 R 337 0 R 338 0 R 339 0 R 340 0 R 341 0 R 342 0 R 343 0 R 344 0 R 345 0 R
346 0 R 347 0 R 348 0 R 349 0 R 350 0 R 351 0 R 352 0 R 353 0 R 354 0 R 355 0 R]
/Parent 2 0 R
/Contents 356 0 R
/Rotate 0
/MediaBox [0.0 0.0 609.449 793.701]
/Resources 357 0 R
/Type /Page
>>
endobj
33 0 obj
<<
/P (1)
>>
endobj
34 0 obj
<<
/Font 358 0 R
/Encoding 359 0 R
>>
endobj
35 0 obj
<<
/Parent 6 0 R
/Next 360 0 R
/Dest [9 0 R /XYZ 72 534 null]
/Title (Abstract)
>>
endobj
36 0 obj
<<
/Parent 6 0 R
/Dest [31 0 R /XYZ 61 134 null]
/Prev 361 0 R
/Title (References)
>>
endobj
37 0 obj
<<
/Font 362 0 R
/ProcSet [/PDF /ImageB /ImageC /Text]
/XObject <<
/Im5 363 0 R
/Im10 364 0 R
/Im9 365 0 R
/Im8 366 0 R
/Im11 367 0 R
/Im7 368 0 R
/Im17 369 0 R
/Im20 370 0 R
/Im4 371 0 R
/Im19 372 0 R
/Im15 373 0 R
/Im3 374 0 R
/Im12 375 0 R
/Im2 376 0 R
/Im6 377 0 R
/Im14 378 0 R
/Im16 379 0 R
/Im18 380 0 R
/Im13 381 0 R
/Im1 382 0 R
>>
/ColorSpace 383 0 R
>>
endobj
38 0 obj
<<
/Type /Annot
/Subtype /Link
/Rect [156.735 42.905 477.585 51.896]
/C [0 0 0]
/Border [0 0 0]
/A 384 0 R
/H /I
>>
endobj
39 0 obj
<<
/Type /Annot
/Subtype /Link
/Rect [324.296 688.444 477.376 696.436]
/C [0 0 0]
/Border [0 0 0]
/A 385 0 R
/H /I
>>
endobj
40 0 obj
<<
/Type /Annot
/Subtype /Link
/Rect [97.1 422.544 247.18 431.914]
/C [0 0 0]
/Border [0 0 0]
/A 386 0 R
/H /I
>>
endobj
41 0 obj
<<
/Type /Annot
/Subtype /Link
/Rect [202.3 401.974 427.29 411.964]
/C [0 0 0]
/Border [0 0 0]
/A 387 0 R
/H /I
>>
endobj
42 0 obj
<<
/Type /Annot
/Subtype /Link
/Rect [326.2 341.461 342.04 350.452]
/C [0 0 0]
/Border [0 0 0]
/A 388 0 R
/H /I
>>
endobj
43 0 obj
<<
/Type /Annot
/Subtype /Link
/Rect [351.4 345.735 489.149 354.726]
/C [0 0 0]
/Border [0 0 0]
/A 388 0 R
/H /I
>>
endobj
44 0 obj
<<
/Type /Annot
/Subtype /Link
/Rect [326.2 291.349 343.78 300.34]
/C [0 0 0]
/Border [0 0 0]
/A 389 0 R
/H /I
>>
endobj
45 0 obj
<<
/Type /Annot
/Subtype /Link
/Rect [351.4 290.835 506.582 299.826]
/C [0 0 0]
/Border [0 0 0]
/A 389 0 R
/H /I
>>
endobj
46 0 obj
<<
/Type /Annot
/Subtype /Link
/Rect [326.2 243.991 341.96 252.982]
/C [0 0 0]
/Border [0 0 0]
/A 390 0 R
/H /I
>>
endobj
47 0 obj
<<
/Type /Annot
/Subtype /Link
/Rect [351.4 247.935 450.44 256.926]
/C [0 0 0]
/Border [0 0 0]
/A 390 0 R
/H /I
>>
endobj
48 0 obj
<<
/Type /Annot
/Subtype /Link
/Rect [106.6 198.471 125.16 207.462]
/C [0 0 0]
/Border [0 0 0]
/A 391 0 R
/H /I
>>
endobj
49 0 obj
<<
/Type /Annot
/Subtype /Link
/Rect [131.8 205.035 232.586 214.026]
/C [0 0 0]
/Border [0 0 0]
/A 391 0 R
/H /I
>>
endobj
50 0 obj
<<
/Type /Annot
/Subtype /Link
/Rect [326.2 201.72 343.8 210.711]
/C [0 0 0]
/Border [0 0 0]
/A 392 0 R
/H /I
>>
endobj
51 0 obj
<<
/Type /Annot
/Subtype /Link
/Rect [351.4 205.035 516.833 214.026]
/C [0 0 0]
/Border [0 0 0]
/A 392 0 R
/H /I
>>
endobj
52 0 obj
<<
/Length 2586
/Filter /FlateDecode
>>
stream
xn%H5HnN)(sdUI3 kcq'~}r?`l\+wE4`ΟOs[K5-bkwk
ޡ?w~^r[`]f
G 03\~^C[kM3yspc(8OQlX`%[lbb) :'dyhUgk%lsPurhvq:#^Hb6'"뤯aD?`m5x6lOO+䮣s.wjs,3.6ݺigS֫_?[b͍ɶ
1?=#=c|Ԏ#*74I0/g,-*͝a5u,YV|9X3\Qei틀jjsַm͌IYimeUgvfH]@YytUزSߡ:cquK[6`4q C"݄>֟',E=Ǿ 9pP2G;{̮CS%~({xhJ'Wa$eksͅ{0
0kic53+œoʡ.blB)#] +o͡$F1^Qa
M#JYK˵jc%pAKt#9i9+#˚;Vk3!6cH@bGPP5l Dfz*Q=ېwrL`UA|Ҁl: {''"Db6Dc$ύstvv: E'U%/`6}M&c*I *#KRBw/)EqB`tx="zq^qJrړ,+}_Z%lM]<yZkgq/¤EJ}~hitú%X{qqUϊm?>('.=]/S`P8]GW@DZ4Ohy o,N
I704)Z,CS{+z¦8xb:3e|HTϡ20UM!#JClm
$x ױ1I>q,=q2=%=LN=% G~?')TF蔺qڑcbW]4}夰Oj{gP~}ޙǮv=u+S>q(JU~wKceCC]W:jGӹRcCgn)*(9$#o{p6;8u>B?Gt^O}}xTuJJ*̙݊'GXƢgd8
b[#!V8ܚbmaSϓv*YұP2Jz3RC-T+BV 3րKPW*8>Ja/o(0m\2lǙTtfeS>*l4`9oI0>&ƴnkQ8e&Z͔!(
'A !/iC{KTRw M)-Cުٓ_,"Rqr&} ߎWSD<[75DZ&G()lwyW:g(laU1,R@R^H(&X
BzZZ͝eԙ,r {ֻp _:;@+@܅Q٫k\/A< 2XY4p ] ɎQͬ|)CGÔDO괣z->j-V6w7'n\9{